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Original Article Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death Thomas J. Wang, M.D., Philimon Gona, Ph.D., Martin G. Larson, Sc.D., Geoffrey H. 3ds Max 2012 Torrent Keygen. Tofler, M.D., Daniel Levy, M.D., Christopher Newton-Cheh, M.D., M.P.H., Paul F.

Jacques, D.Sc., Nader Rifai, Ph.D., Jacob Selhub, Ph.D., Sander J. Robins, M.D., Emelia J. Benjamin, M.D., Sc.M., Ralph B. D'Agostino, Ph.D., and Ramachandran S. N Engl J Med 2006; 355:2631-2639 DOI: 10.1056/NEJMoa055373. Results During follow-up (median, 7.4 years), 207 participants died and 169 had a first major cardiovascular event. F4u Corsair Blueprints Pdf File. In Cox proportional-hazards models adjusting for conventional risk factors, the following biomarkers most strongly predicted the risk of death (each biomarker is followed by the adjusted hazard ratio per 1 SD increment in the log values): B-type natriuretic peptide level (1.40), C-reactive protein level (1.39), the urinary albumin-to-creatinine ratio (1.22), homocysteine level (1.20), and renin level (1.17).

The biomarkers that most strongly predicted major cardiovascular events were B-type natriuretic peptide level (adjusted hazard ratio, 1.25 per 1 SD increment in the log values) and the urinary albumin-to-creatinine ratio (1.20). Persons with “multimarker” scores (based on regression coefficients of significant biomarkers) in the highest quintile as compared with those with scores in the lowest two quintiles had elevated risks of death (adjusted hazard ratio, 4.08; P. Figure 2 Receiver-Operating-Characteristic Curves for Death (Panel A) and for Major Cardiovascular Events (Panel B) during 5-Year Follow-up.

For each end point, curves are based on models of the prediction of risk with the use of conventional risk factors with or without biomarkers (multimarker score). Biomarkers for death were B-type natriuretic peptide, C-reactive protein, the urinary albumin-to-creatinine ratio, homocysteine, and renin. Biomarkers for major cardiovascular events were B-type natriuretic peptide and the urinary albumin-to-creatinine ratio. Established cardiovascular risk factors, including dyslipidemia, smoking, hypertension, and diabetes mellitus, have been incorporated into algorithms for risk assessment in the general population, but these characteristics do not fully explain cardiovascular risk.